Saturday, April 6, 2013

Tony Sachs: Can Angostura's $25,000 Rum Change Perceptions of the Category?

It was a Wednesday afternoon. I was taking care of my two-year-old daughter when the phone rang. It was my friend, publicist James Monahan. "How are you, my friend?

"Cut to the chase, pal," I said tersely. "The kid doesn't like it when Daddy talks on the phone."

Over her shouting and the gripping dialogue of her favorite cartoon, Wow! Wow! Wubbzy!, I caught only a few snippets of what James was saying. But it was enough. "Angostura... rum... expensive... limited edition... dinner...." But the snippet that most caught my ear and captured my imagination was this: "$25,000."

Now, it wasn't just that I was intrigued by the thought of drinking something that costs 1,000 times as much as an average bottle of dark sipping rum -- although of course I wasn't about to turn down such an opportunity. No, this audacious, downright ballsy product launch could represent a sea change in how rum is presented and marketed, and with any luck how it's perceived as well. Single malt Scotch whiskies that sell for thousands, even tens of thousands of dollars are... well, not a dime a dozen obviously. But they're becoming more commonplace with each passing year. Along with cognac, single malts are the status symbols of the spirits world.

So what's Scotch got that rum -- namely Legacy by Angostura, as their new $25,000 super-limited edition is called -- hasn't got? After all, a really good aged sipping rum is as complex and delicious and mind-blowing as any whisky or cognac. And if there's a brand that can take rum to the next level of snob appeal, it's Angostura. They're better known for their legendary bitters, but they've also been making the best rums in Trinidad, and some of the best anywhere in the Caribbean, since the 1940s.

Angostura makes rums both for mixing and for sipping, but the flavor profile -- rich, ultra-smooth, with gobs of vanilla, toffee, honey, and varying degrees of oak depending on how long it's aged -- remains constant throughout the range. My favorite is the 12-year-old "1824" bottling, with spice and oak notes combining with the sweet flavors to form a more perfect union in your mouth. It's soothing and challenging at the same time -- and at $55, it's very reasonable compared to more glamorous top-of-the-line whiskies.

In fact, with precious few exceptions, ultra-premium rums simply don't compare, price-wise, with their single-malt counterparts. If you're into rum, of course, that's a great thing. But it also means that the marketplace perceives rum to be a lot less valuable than single malt whisky. It seems to me there are two reasons why. First, a lot of would-be connoisseurs whose disposable income exceeds their knowledge of spirits aren't buying a bottle of booze so much as they're buying an age statement. And the older the age, the sexier the contents of the bottle, regardless of what they taste like. Scotland's cool and damp climate allows for aging whiskies as long as 30, 40, 50 years or more. Rum, on the other hand, is aged in tropical climes that speed up the aging process, making a bottle of 10-year-old rum the equivalent of a single malt that's two or three times as old. And 10... well, it's just not as sexy as 18 or 21 or 30.

Then there's the Bacardi Factor. A single malt whisky, whether it's $30 or $300 or $30,000, beings to mind the same things -- class, sophistication, luxury. And rum? Yeah, it's that clear stuff you put in your mojitos and frozen strawberry daiquiris, or you can drink it with Diet Coke if you're low-carbing. Right?

Well, Legacy by Angostura, the self-proclaimed "World's Most Expensive Rum," is here to put lie to that myth. With a blend of rums aged a minimum of 17 years in once-used American bourbon oak casks, housed in an Asprey crystal decanter with a gorgeous sculpted silver stopper, limited to a minuscule 20 bottles worldwide (a mere three in the U.S.), the good folks at Angostura are pulling out all the stops with this one. Angostura's Master Distiller, John Georges, is being flown around the globe to launch Legacy and sing the praises of Angostura in general. Which is why I found myself with a small group of journalists at a swanky Upper East Side restaurant, sitting across from Mr. Georges and geeking out about the finer details of rum distillation with him while sipping our way through Angostura's line.

When our glasses of Legacy -- valued, by my reckoning, at more than $1,000 each -- were brought out, Georges was less loquacious than he'd been throughout the evening. Perhaps even a little overwhelmed. He and the other distillers and blenders at Angostura had worked for six years, he said, using some of Angostura's rarest rums, and he believed the end result was truly the greatest sipping rum ever made. I can't quote him exactly because I was too busy staring at my ounce or so of Legacy trying to figure out how much each drop was worth.

Does it taste like a $25,000 rum? Well, I'm not exactly the target audience, meaning that I look at 25 grand as, you know, money to live on for a good chunk of time. If Mariano Rivera was there to personally pour it for me while Christina Hendricks rubbed my shoulders, possibly. But Legacy is more than just a bold and audacious marketing move. I'll tell you, this rum has ... gravitas. It's big, profound, monumental, but not without a touch of lightness and a twinkle in its proverbial eye. For some reason, the image of Winston Churchill popped into my head while I took my first sip. It's recognizably Angostura, with those distinctive vanilla and honey notes, but it's deeper and richer, with more spice and wood, notes of dark fruit and nuts, and a long, oaky finish. And having been lucky enough to taste a few five-figure whiskies, I'll assert that Legacy can stand proudly alongside the best of them.

If there's one rum that can change people's perceptions about what rum is, and what it can be at its best, this is as good a candidate as any. I guess the real question is, can any one rum accomplish the monumental task of overcoming the Bacardi Factor? Perhaps not, but this is an impressive opening salvo. Remember, twenty years ago tequila suffered from the same perception -- the Cuervo Factor, if you will. Today, in addition to the margaritas-and-body-shots crowd, there's a large and growing market for ultra-premium sipping tequilas, with increasing demand to go along with improved quality. It wasn't achieved overnight, with one limited edition bottling, but it did happen. I'm guessing the same will hold true for rum over the next several years. It's been an "on the brink" spirit for ages, but its breakthrough may finally be nigh. And hopefully Legacy will help open minds as much as it opens wallets.

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Follow Tony Sachs on Twitter: www.twitter.com/RetroManNYC

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Source: http://www.huffingtonpost.com/tony-sachs/angosturas-rum_b_3014216.html

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Jim Carrey video the gun nuts are seething over (Americablog)

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Friday, April 5, 2013

Cancer checkpoint: Mitochondrial metabolic regulator SIRT4 guards against DNA damage

Apr. 4, 2013 ? Healthy cells don't just happen. As they grow and divide, they need checks and balances to ensure they function properly while adapting to changing conditions around them.

Researchers studying a set of proteins that regulate physiology, caloric restriction and aging have discovered another important role that one of them plays. SIRT4, one of seven sirtuin proteins, is known for controlling fuel usage from its post in the mitochondria, the cell's energy source. It responds to stressful changes in the availability of nutrients for the cell.

New research reveals that SIRT4 is also extremely sensitive to a different form of stress: DNA damage. This unsuspected response by the metabolic checkpoint means SIRT4 doubles as a sentry guarding against cancer, which is spurred by genetic abnormalities.

Sirtuins have become familiar for their connection to longevity and to resveratrol, the red-wine compound that activates SIRT1, but less attention has been focused on SIRT3, SIRT 4 and SIRT5, all of which are found in mitochondria. Marcia Haigis, HMS associate professor of cell biology, led a team that has uncovered SIRT4 as an important player in the DNA damage response pathway, coordinating a sequence of events that normally result[s] in tumor suppression. They published their results April 4 in Cancer Cell.

"When we started studying SIRT4, we were focused only on its metabolic role, looking for functions related to diabetes and obesity," said Haigis. "What we found, to our surprise, was that SIRT4 was responsive to DNA damage, so that led us to investigate the metabolic response to DNA damage and how SIRT4 controls the metabolic response to genotoxic stress."

To see how SIRT4 normally functions, Haigis and her colleagues induced DNA damage by exposing cells in a lab dish to ultraviolet light. This damage triggered a halt in glutamine metabolism, limiting the amount of nutrients the cell could use as it goes through a cycle of division and growth.

Blocking the cell cycle at this juncture is important. If cell growth after DNA damage goes unchecked, proliferation of impaired cells can lead to cancer. When SIRT4 works properly, this chain of events is broken before bad cells and their abnormal genes multiply. SIRT4 blocks glutamine metabolism, arrests the cell cycle and suppresses tumor formation.

The scientists tested this SIRT4 response in mice. Bred to lack the gene that encodes the SIRT4 protein but otherwise normal, the mice spontaneously developed lung cancer by 15 months.

"When SIRT4 is missing, you don't have this metabolic checkpoint involving glutamine, which is important because glutamine is an amino acid required for proliferation in the cell," Haigis said. "Without SIRT4, the cell keeps dividing even in the face of DNA damage, so the cell accumulates more damage."

The scientists also analyzed data showing SIRT4 gene expression levels are low in several human cancers, including small-cell lung carcinoma, gastric cancer, bladder carcinoma, breast cancer and leukemia.

While they cannot say if SIRT4 loss alone will initiate cancer, its absence appears to create an environment in which tumor cells survive and grow.

"Our findings suggest that SIRT4 may be a potential target against tumors," they conclude.

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Story Source:

The above story is reprinted from materials provided by Harvard Medical School. The original article was written by Elizabeth Cooney.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Seung?Min Jeong, Cuiying Xiao, Lydia?W.S. Finley, Tyler Lahusen, Amanda?L. Souza, Kerry Pierce, Ying-Hua Li, Xiaoxu Wang, Ga?lle Laurent, Natalie?J. German, Xiaoling Xu, Cuiling Li, Rui-Hong Wang, Jaewon Lee, Alfredo Csibi, Richard Cerione, John Blenis, Clary?B. Clish, Alec Kimmelman, Chu-Xia Deng, Marcia?C. Haigis. SIRT4 Has Tumor-Suppressive Activity and Regulates the Cellular Metabolic Response to DNA Damage by Inhibiting Mitochondrial Glutamine Metabolism. Cancer Cell, 2013; DOI: 10.1016/j.ccr.2013.02.024

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/g2hXsrHcg8E/130405094517.htm

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Audi Connect gets new T-Mobile data plans

Audi Connect gets new T-Mobile data plans

If a vehicle outfitted with Audi Connect has found its way into your garage, T-Mobile has a pair of new data plans for you to consider. Dropping $450 nets car owners 30 months of "full data services" to power the infotainment system, which packs features including Google Earth, real-time Sirius XM Traffic info and even WiFi for up to eight devices. Drivers who aren't in the market for such a long term commitment can pony up $30 every month instead. Hit the jump for the full press release from Audi and the UnCarrier.

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Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/lr2Yex1L630/

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Motive sought in slaying of West Virginia sheriff

(Reuters) - West Virginia investigators searched on Thursday for a motive in the shooting death of a sheriff killed as he ate lunch in his vehicle, and his alleged attacker remained in critical condition after being shot by police.

The suspect, Tennis Maynard, 37, of Ragland, West Virginia, has been charged with first-degree murder and attempted murder in the Wednesday shooting of Mingo County Sheriff Eugene Crum, 59, who was killed in his police SUV in Williamson.

The shooting occurred amid a heightened awareness of attacks on U.S. law enforcement officials after two prosecutors in one Texas town and the Colorado prisons chief were killed in apparent targeted attacks this year.

Crum, a former magistrate, took office as sheriff at the beginning of the year vowing to crack down on drug trafficking. He and a local task force made 50 drug-related arrests in February.

Police said that after Crum was shot on Wednesday, Maynard fled the scene and crashed his car after a high-speed chase, and a sheriff's deputy shot him several times when he pointed a pistol at him.

Maynard was airlifted to a hospital, where he was in critical condition but was expected to survive, state police spokesman Sergeant Michael Baylous said.

"He's still on a ventilator and we have not been able to talk to him," he said.

Investigators have not specified a suspected motive for the shooting. Asked if it was related to Crum's crackdown on prescription-pill trafficking, Sheriff's Department Corporal Norman Mines said it was possible.

"But we're not going to focus on one motive," said Mines, the officer who shot Maynard.

He said Maynard spoke briefly after being shot, but Mines and Baylous said the comments were mostly garbled.

The suspect's father, Melvin Maynard, told WSAZ-TV in Huntington on Wednesday that his son had developed mental problems after being exposed to chemicals on a job in Alabama, and had no vendetta against police.

The state police said a .40 caliber Glock handgun thought to have been used to shoot Crum was recovered at the crash scene. The Mingo County Commission appointed Crum's widow, Rosie, interim sheriff.

The National Law Enforcement Officers Memorial Fund said 28 officers had been killed in the line of duty in the United States since April 3, 2012, including 13 killed with firearms.

(Reporting by Ian Simpson in Washington and Lee Mueller; Editing by Cynthia Johnston and Eric Beech)

Source: http://news.yahoo.com/motive-sought-slaying-west-virginia-sheriff-001802516.html

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Maryland set to become latest state to enact stiff gun-control measure

WASHINGTON (Reuters) - Maryland was set to become the latest U.S. state to enact stiff gun control measures, with the approval on Wednesday by the state's House of Delegates of legislation that includes a ban on dozens of assault weapons and limits on magazine size.

The legislation, which had been proposed by Governor Martin O'Malley, was passed by the state Senate last month.

Colorado and New York have already passed new laws on gun control, and the Connecticut legislature was set to vote on Wednesday on what supporters describe as one of the toughest gun measures in the country.

Maryland's Democratic-controlled House voted 78 to 61 to pass the measure, sending it to O'Malley to be signed.

"We're so close to enacting common sense reforms," O'Malley posted on Twitter, moments after the bill's passage.

Maryland lawmakers joined others in seeking to tighten controls on firearms following the December massacre of 20 schoolchildren and six adults in Newtown, Connecticut.

The legislation limits magazine capacity to 10 bullets, requires that gun buyers be fingerprinted and licensed, and places new limits on weapons purchases by the mentally ill.

The legislation also bans more than 40 types of existing assault rifles, including all models of the AR-15. That weapon was used in the Newtown attack, by accused Aurora, Colorado, shooter James Holmes, and by Washington's "Beltway sniper" in 2002.

A House committee pulled from the bill part of O'Malley's proposal that set out physical characteristics used to weigh whether weapons made in the future should be banned as well.

Critics have contended that the removal of that proposal from the bill creates a loophole that could allow future types of weapons to be legal that otherwise would be banned.

The package also allows the purchase of assault weapons after October 1, when the law takes effect, as long as they can prove that the sale was initiated before it took effect.

(Reporting by Ian Simpson, additional reporting by Lacey Johnson; Editing by Scott Malone and Leslie Adler)

Source: http://news.yahoo.com/maryland-set-become-latest-state-enact-stiff-gun-223024225.html

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Roger Ebert, the Heart and Soul of the Movies, Has Died

DEAR ABBY: My husband, "Wade," and I went into a convenience store near our home that we frequent regularly. A new employee -- a pretty, much younger girl -- stared at Wade with an expression of recognition and surprise on her face. When I asked him what that was about, he laughed it off and said I was "imagining things."The next time we saw her, Wade acted nervous and started talking fast, as if trying to distract me. He seemed to be avoiding eye contact with her. She ignored me while obviously trying to lock eyes with Wade. ...

Source: http://news.yahoo.com/roger-ebert-heart-soul-movies-died-193948667.html

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