Boeing 787 Dreamliner completes first Trans-Pacific passenger flight, lands in Boston as JAL 8

We've been fortunate enough to hitch a ride on Boeing's 787 within the Land of the Rising Sun, but now the Dreamliner has hopped the Pacific with passengers on board, departing Tokyo Narita and landing at Boston's Logan International Airport around noon on Sunday. The JAL service marks New England's first Asia route, enabled by the 787's efficient design which lets airlines fly to lower-demand cities without wasting fuel on empty seats. The 787 will be making the 6,869-mile journey four times a week through May 31st, at which point daily service will begin, with flight 7 departing Boston at 1:20PM and arriving in Tokyo at 4 the following afternoon. Passengers on flight 8 will leave Tokyo at 11:30AM and land in Boston at 11:20AM on the same day. This is likely to be your best opportunity to ride a US-bound Dreamliner until United begins service later this year, so hit up the source link to get your fix, priced upwards of $1,500 for dates throughout the summer.

Boeing 787 Dreamliner completes first Trans-Pacific passenger flight, lands in Boston as JAL 8 originally appeared on Engadget on Mon, 23 Apr 2012 23:28:00 EDT. Please see our terms for use of feeds.

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New BeoPlay V1 shows up ahead of time, hearts and wallets flutter

We're more used to phones getting leaked ahead of time, but it's not always just the latest and greatest handset that sneaks its way into our inbox. Danish website Recordere has managed to get a cheeky glimpse of the new BeoPlay V1 TV from Bang and Olufsen. Pegged as the new "affordable" model from the Scandinavian manufacturer, it'll come in two flavors: the BeoPlay V1-32 and V1-40 (the numbers representing screen size,) which include DLNA functionality, five HDMI ports, one USB, and integrated 5.1 surround sound, as well as a few other treats. The official launch is the 5th of May, with pricing set at €2,399 and €2,899 (about $3,170 and $3,831 respectively) depending how big the space in your front room is.

New BeoPlay V1 shows up ahead of time, hearts and wallets flutter originally appeared on Engadget on Sun, 22 Apr 2012 05:13:00 EDT. Please see our terms for use of feeds.

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Samsung countdown teases next Galaxy phone with anagram

Sammy's latest marketing ploy kicked off with a string of nonsense that could just as easily have come from the Sunday morning jumble: "Destination: tgeltaayehxnx," declared the Samsung Mobile Twitter account. Anagram wizards will read that as, "the next Galaxy," and wouldn't you know it, it's also the URL for an auspicious countdown clock. Sammy promises to let visitors take "the next step" in about 17 hours and counting. Bonafide internet sleuths can find an extra carrot strung up in the site's source, reading, "discover how Samsung is about to challenge the way you view the Galaxy once more." Is Samsung about to break its own May 3rd unveiling? We'll let you know in 16 hours and change.

Update: It seems like that ticker just might be counting down to some sort of anagram guessing game, according to an Engadget tipster who partook in some directory diving. Among a series of assets of different colored lettered tiles he found images with instructions warnings, reading "Click on the letters in the correct order to reveal your real destination," and "Following technology blindly often gets you nowhere." Ominous.

[Thanks, Naor]

Samsung countdown teases next Galaxy phone with anagram originally appeared on Engadget on Sun, 22 Apr 2012 14:26:00 EDT. Please see our terms for use of feeds.

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Keep up with Facebook, Twitter, RSS, and more while your iPhone is docked with Dock for iPhone

Dock is an iPhone app that acts as as screensaver of information when your iPhone is not in use. While your iPhone is docked at your desk, Dock will scroll through weather, RSS, Twitter, Facebook, Clock and Stock widgets.

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EU supports Novartis MS pill with stronger warning

LONDON (Reuters) - European regulators have endorsed the continued use of Novartis AG's multiple sclerosis pill Gilenya, one of the Swiss firm's top new drug hopes, but said on Friday the drug needed to carry stronger warnings on heart risks.

Novartis said the decision meant the drug remained on-track to be a "blockbuster" - one with annual sales above $1 billion.

Prospects for Gilenya, the first multiple sclerosis (MS) pill of its kind, have been clouded by reports of its association with serious heart problems.

The European Medicines Agency (EMA), which had initially aimed to give an update on Gilenya last month, said doctors should not prescribe it to patients with a history of cardiovascular and cerebrovascular disease or those on heart-rate lowering medication.

If treatment with Gilenya was considered necessary in these patients, however, their heart activity should be monitored at least overnight following the first dose of the drug, it said.

All patients getting the drug should have an electrocardiogram (ECG) and a blood pressure measurement prior to the first dose and after a six-hour initial period, during which continuous ECG monitoring is recommended.

A committee of EMA experts said the possible risk of heart problems could be limited by these stronger warnings.

"With these risk-minimization measures in place, the committee concludes that the benefits of Gilenya continue to outweigh the risks," the agency said in a statement.

David Epstein, head of Novartis Pharmaceuticals, said he welcomed EMA's confirmation of Gilenya's positive benefit-risk profile "which also supports our continued belief of the blockbuster potential of Gilenya".

WORST CASE AVOIDED

Analysts said there would be relief that the drug had not been pulled off the market but safety concerns would linger.

Martin Voegtli at Kepler Capital Markets said the strengthened warnings against prescribing in patients with cardiovascular risk factors would restrict the patient population and hit sales forecasts.

But Tim Race of Deutsche Bank viewed the EMA verdict more positively, since it ruled out the worse-case scenarios of either product removal or overnight monitoring for all patients.

Shares in Novartis were 0.6 percent higher at 1000 GMT, broadly in line with the European drugs sector.

Gilenya is still seen by analysts as a big seller, with annual sales of $1.7 billion by 2015, according to consensus forecasts collected by Thomson Reuters Pharma. But that is down on the $2.2 billion forecast in late 2011, due to safety fears.

In recent months, doctors have grown more cautious about the drug following reports of heart problems in some patients and the death of one person in the United States within 24 hours of starting treatment.

Those cases prompted the EMA to start its review in January, when it first advised doctors to continuously monitor patients for six hours after giving them a first dose. The U.S. Food and Drug Administration (FDA) is also looking into the drug.

Gilenya represents a significant change in MS treatment, since existing medicines like beta interferons and Elan and Biogen Idec's Tysabri must be injected.

Rival oral MS treatments in development include BG-12 from Biogen, teriflunomide from Sanofi and laquinimod from Teva.

(Reporting by Ben Hirschler; Editing by Kate Kelland and Helen Massy-Beresford)

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Reasons Why Internet Marketing is So Powerful | FitnessA-Z ...

If you are not comfortable with adelaide carpet cleaners and executing quick and important decisions, then it is critical that you know that ability is indispensable with online marketing and business. It is a fact that a very high percentage of new businesses fail in the first few years. If there is no clue at all as to how to get started in the first place, then welcome to the club and learn to deal with it for a while at least. Bear in mind that millions have gone before you, and you are capable of learning how to cope with new experiences. The issue of mistakes in business need not be only because you are learning and mistakes are to be expected. It is like anything else you start learning, in time the errors will be less and you will be more confident. While you really should always perform due diligence, we have no issue with that when it comes to the methods outlined below. There's no doubt about it: internet marketing has really taken off in recent years. Today, people are feeling more secure about ordering products and services online. At the same time as customers feel more secure, businesses in turn are realizing how profitable online marketing can be. Shopping online is quickly getting to be as normal and commonplace as shopping at the mall; online sales will soon be in the billions. If current trends continue, online marketing will only expand further, making this an ideal time to start your own internet business. Online marketing has already created many millionaires, many of whom now have businesses that practically run themselves. It is necessary to put in the time and hard work to get an internet business off the ground, but in the long run it's well worth it. It's very possible to have your business take off to great heights once you learn the ropes. There aren't many other businesses where you can start out on a shoestring budget and become wealthy in a few short years. 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If you don't mind spending a little money, you can also purchase various online courses, ebooks and software that can help your business get off the ground. But there are always many free sources of information for those on a tight budget. Another good source of information are forums on internet marketing; read some of the threads and ask any questions you may have and you'll learn from people who have been at this for a long time. As you are going along and working your business, you will learn new ways to promote your offers; so what you need to do is hypothetically apply them to what you do and see if it is viable. Since we have no idea how you market or what your model is, we do realize that carpet cleaners melbourne could be partially useful or maybe not at all depending on your situation. Just how far do you want to take things online? That is always a valid and important question to ask. But, we tend to believe the universal answer to the question of growth is, yes. It only makes sense that you will want to entertain processes you have not yet used. You have heard about all the shrewd business people who have taken every opportunity that comes across their desk if it would work with what they do in business. In conclusion, there's no reason why you shouldn't try your hand at internet marketing. It will be one of the best decisions you will make. Rest assured, you have just received an introduction about these techniques. Any time you read an article that talks about online marketing methods pertaining to brisbane carpet cleaning or anything else, just assume there is much more to the story. Now what you want to do, or should do, after reading this is go out and find out more. Avoid the trap of staying in book learning mode and constantly moving from one thing to the next. If that scenario is you, then start slowly but be sure you force your self to do something each business day. Start thinking in terms of activities that help you earn or generate profits.

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Bhopal protesters unveil banner outside Olympic Stadium

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